L-Arginine is an essential amino acid for infants and growing
children, and it is a conditionally essential amino acid for adult
mammals, as it is important in situations in which requirements
exceed production,such as pregnancy.

L-Arginine is a substrate for at least five enzymes identified in
mammals, including arginase,arginine-glycine transaminase,
kyotorphine synthase, nitric oxide synthase (NOS) and arginine
decarboxylase. It has a significant metabolic role as the product of
ammonia detoxification, the urea cycle metabolite, the precursor of
proteins, ornithine, urea and creatinine, and the amino acid
involved in the formation of active enzyme centers. Its side effects
are rare and mostly mild and dose-dependent.

L-arginine is the substrate for the enzyme nitric oxide synthase
(NOS), which is responsible for the production of nitric oxide (NO),
an endogenous messenger molecule involved in many of the
processes associated with the development of atherosclerosis.
Acute and chronic administration of L-arginine has been shown to
improve endothelial function in animal models of
hypercholesterolemia and atherosclerosis.

A few studies suggest the side effect of L-arginine
supplementation is mild and dose-dependent. However, High dose
of L-arginine intraperitoneal administration has been reported to
cause side effects, such as pancreatitis.

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L-Arginine
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